Hartwig silylation
WebJun 10, 2024 · The resting state of the catalyst is an iridium disilyl hydride complex (phenanthroline)Ir (SiMe (OTMS) 2) 2 (H) (L), in which L varies with the arene and additives. An iridium disilyl hydride complex was isolated, characterized, and allowed to react with arenes to form aryl silanes. WebAngewandte Chemie International Edition Communication A Chiral Nitrogen Ligand for Enantioselective, Iridium-Catalyzed Silylation of Aromatic C−H Bonds Dr. Bo Su, Dr. Tai-Gang Zhou, Dr. Xian-Wei Li, Xiao-Ru Shao, Pei-Lin Xu, Dr. Wen-Lian Wu, Prof. Dr. John F. Hartwig, Prof. Dr. Zhang-Jie Shi First published: 15 December 2016
Hartwig silylation
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WebThe functionalization of primary C–H bonds has been a longstanding challenge in catalysis. Our group has developed a series of silylations of primary C–H bonds that occur with site selectivity and … WebFeb 21, 2014 · Regioselective C-H functionalization of arenes has widespread applications in synthetic chemistry. The regioselectivity of these reactions is often controlled by …
WebApr 13, 2024 · Inventors: John F. Hartwig, Hanna M. Key, Pawel Dydio, Douglas S. Clark Intermolecular C-H silylation of unactivated arenes Patent number: 9938204 Abstract: Reaction mixtures for silvlating arene substrates and methods of using such reaction mixtures to silyiate the arene substrates are provided. WebFeb 4, 2015 · The silylation proceeds under mild conditions, in the absence of hydrogen acceptors, ligands or additives, and is scalable to greater than 100 grams under …
WebFor postdoc, Erik moved to Prof. John Hartwig's lab at UC Berkeley to identify conditions enabling novel silylation methods of alkyl C-H bonds. Upon his move back to UCSD to … WebJun 19, 2012 · Based on this hypothesis, we studied catalysts containing substituted phenanthroline ligands for a series of additional transformations, including the silylation …
WebAug 2, 2024 · The design of this silylation of C–H bonds is shown in Scheme 4.Although the borylation of alkyl C–H bonds has been established, and one might imagine that intramolecular borylation of C–H bonds would be faster than intermolecular borylation, it is difficult to envision how the borylation of C–H bonds could be conducted …
WebThe combination of [Ir (cod) (OMe)]2 and 2,9-Me2-phenanthroline (2,9-Me2-phen) catalyzes the silylation of arenes at lower temperatures and with faster rates than those reported previously, when the hydrogen byproduct is removed, and with high functional group tolerance and regioselectivity. hopkins flotool 10714mx3 super funnel trioWebMay 7, 2024 · The resting state of the catalyst is an iridium disilyl hydride complex (phenanthroline)Ir (SiMe (OTMS) 2) 2 (H) (L), in which L varies with the arene and additives. An iridium disilyl hydride complex was isolated, characterized, and allowed to react with arenes to form aryl silanes. long tongue monster sweet homeWebSep 6, 2024 · We report highly enantioselective intramolecular, silylations of unactivated, primary C(sp3)-H bonds. The reactions form dihydrobenzosiloles in high yields with excellent enantioselectivities by functionalization of enantiotopic methyl groups under mild conditions. The reaction is catalyz … hopkins flowersWebSep 9, 2015 · Catalytic Silylation of Unactivated C-H Bonds Catalytic Silylation of Unactivated C-H Bonds Chem Rev. 2015 Sep 9;115 (17):8946-75. doi: … long tongue peopleWebJan 4, 2024 · Transition metal-catalyzed bis-silylation of alkynes with disilanes is the most straightforward strategy to access such useful building blocks. ... C. & Hartwig, J. F. Catalytic silylation of ... long tongue telegramWebTransition-metal-catalyzed enantioselective C–H silylation is one of the most effective ways to access silicon-containing chiral molecules, which have great utility in areas ranging from synthetic chemistry and medicinal chemistry to materials science. long tongue strike plateWebDec 16, 2014 · A method for the iridium-catalyzed silylation of aryl C–H bonds is described. The reaction of HSiMe(OSiMe3)2 with arenes and heteroarenes catalyzed by the … long tongue newgrounds