Glut1 overexpression
WebOverexpression of GLUT1 in the tumor tissues from PDX#1 was observed compared with that from PDX#2 (Figure 7B). We found that high-dose ascorbate or oxaliplatin alone could suppress tumor growth, while the combination of both agents induced more potent antitumor activity as evidenced by the significantly decreased tumor growth and tumor weight ... WebActivation of glycolytic activity by LDHA overexpression induced immunosuppression and pro-tumour functions in neutrophil-like differentiated HL-60 (dHL-60) cells. Mechanistic studies revealed BHLHE40, downstream to hypoxia and endoplasmic reticulum stress, was a key regulator in polarisation of neutrophils towards TAN-1 phenotype, and direct ...
Glut1 overexpression
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WebSep 19, 2013 · Background. Increased glucose transporter 1 (GLUT1) expression and glucose utilization that accompany pressure overload‐induced hypertrophy (POH) are … WebFeb 4, 2024 · For evaluated the effect of MUC16 overexpression or down-regulation on the basal expression of GLUT1, subsequent Western blotting (WB) was executed and the result showed that altered expression of MUC16 can change the expression of GLUT1 (Figure 4A), gray value analysis revealed statistically significant differences among the groups …
WebNov 1, 2024 · In contrast, GLUT1 overexpression attenuated the BPIFB1-induced inhibition of tube formation in NPC cells as well as VEGFA, VE-cadherin, and MMP2 expression (Fig. 3D–F). These data indicate that ... WebMar 14, 2014 · To increase glucose uptake, we stably overexpressed the GLUT1 transporter in RAW264.7 MΦs (GLUT1-OE MΦs). Cellular bioenergetics analysis, metabolomics, and radiotracer studies demonstrated that GLUT1 overexpression resulted in elevated glucose uptake and metabolism, increased pentose phosphate pathway intermediates, with a …
WebGLUT1, a glucose transporter necessary in cementogenesis, was inhibited by SIRT6. Overexpressing GLUT1 in SIRT6-overexpressed OCCM-30 cells rescued the inhibitory effect of SIRT6 on cementoblast differentiation and mineralization. ... Meanwhile, GLUT1 overexpression significantly decreased AMPK activity. Overall, on one hand, SIRT6 … WebTo better understand the role that RRAD plays in glucose metabolism, the levels of proteins related to aerobic glycolysis were determined. GLUT1 was upregulated with knockdown of RRAD while overexpression of RRAD led to a lower GLUT1 level. However, other proteins associated with glucose metabolism showed no significant alteration .
WebJun 5, 2014 · HIF-1α and GLUT1 are critical for OGT-mediated regulation of metabolic stress as overexpression of stable HIF-1 or GLUT1 rescues metabolic defects and apoptosis. Human basal-like breast cancers with high levels of HIF-1α contain elevated OGT, O-GlcNAcylation and lower OGA levels correlate independently with poor patient …
WebApr 1, 2009 · Indeed, GLUT1 overexpression was associated with parameters conferring more aggressive behavior in several solid tumor types. 11, 12 Actually, we found that GLUT1 expression was a rate-limiting factor for the uptake of … number of rows in a pandas dataframeWebNov 20, 2000 · We have recently shown that Glut1 has limited expression in normal tissues but can be detected by immunohistochemistry in a variety of malignant neoplasms, including nonsmall cell lung carcinoma (NSCLC). 24 Glut3 is also expressed in NSCLC. 25 Whereas Glut1 overexpression in colon carcinoma was found to be associated with an increased … nintendo switch windows 95WebMar 13, 2024 · SIRT1 overexpression or GLUT1 overexpression alone was sufficient to promote cell proliferation and glucose uptake in BC cells. EX527, a specific inhibitor of SIRT1, exerted an opposing effect on bladder cancer proliferation and glucose uptake. The effect of EX527 could be partially reversed by GLUT1 overexpression. nintendo switch windows 10 armWebJun 20, 2024 · Overexpression of LAIR-1 in OS cells inhibits Glut1 expression and may further regulate glucose metabolism, thus inhibiting EMT and OS progression. … number of rows in table javascriptWebFeb 28, 2014 · [25][26] [27] In addition, the expression of GLUT1 often correlates with the ability to detect tumors by PET. 49 Overexpression of GLUT1 gene has been shown to confer two-to fivefold higher drug ... number of rows in a numpy arrayWebAug 3, 2011 · Overexpression of GLUT1 in a cell line with low levels of endogenous GLUT1 increased glucose transport in vitro and enhanced growth in nude mice in vivo as compared to the control cells with very … number of rows in array pythonWebMar 23, 2015 · Overexpression of GLUT1 inhibits cell death triggered by DHA. The data shown above indicated that DHA-induced cytotoxicity in NSCLC cells was associated … number of rows is not the same across batches