Electric-field-stimulated protein mechanics
WebSep 19, 2024 · Here, the tubulin dimer’s response to external electric fields was determined by atomistic simulation. External fields from 50 to 750 kV/cm, applied for 10 ns, caused significant conformational rearrangements that were dependent upon the field’s directionality. Charged and flexible regions, including the α:H1-B2 loop, β:M-loop, and C ... WebJan 5, 2024 · Electric fields are involved in numerous physiological processes, including directional embryonic development and wound healing following injury. To study these processes in vitro and/or to harness electric field stimulation as a biophysical environmental cue for organised tissue engineering strategies various electric field …
Electric-field-stimulated protein mechanics
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WebJun 1, 2024 · Electric field is a critical issue for the migration and assembly of molecules during protein crystallization. This article covers the effects of external and internal electric field on the regulation and harvest of high-quality protein crystals. Emphasis is placed on contributions from electric fields strength, direction, frequency, and ... WebThe method, “EF-X”, combines the use of strong electric field (EF) pulses with time-resolved X-ray crystallography to exert precise, controlled patterns of force …
WebDec 7, 2016 · Using a human PDZ domain (LNX2 (PDZ2)) as a model system, we show that protein crystals tolerate electric field pulses strong enough to drive concerted motions … WebThe method, electric field–stimulated X-ray crystallography (EF-X), combines the use of strong electric field pulses to drive motions within protein crystals with simultaneous …
Webelectric field pulses to protein crystals with time-resolved X-ray crystallography to observe conformational changes in spatial and temporal detail. Using a human PDZ domain … WebOct 16, 2024 · The bio-based industry is urged to find solutions to meet the demands of a growing world population. In this context, increased resource efficiency is a major goal. Pulsed electric field (PEF) processing is a promising technological solution. Conventional PEF and the emerging area of nanosecond PEF (nsPEF) have been shown to induce …
WebThe internal mechanics of proteins-the coordinated motions of amino acids and the pattern of forces constraining these motions-connects protein structure to function. Here we …
WebMy Research and Language Selection Sign into My Research Create My Research Account English; Help and support. Support Center Find answers to questions about products, access, use, setup, and administration.; Contact Us Have a question, idea, or some feedback? We want to hear from you. indian oil online gas refill bookingWebDec 7, 2016 · The induced motions are subtle, involve diverse physical mechanisms, and occur throughout the protein structure. The global pattern of electric-field-induced … indian oil officers holiday homeWebSep 30, 2015 · Electric-field-stimulated protein mechanics. Hekstra, D.R., White, K.I., ... The internal mechanics of proteins-the coordinated motions of amino acids and the pattern of forces constraining these motions-connects protein structure to function. ... Here we describe a new method combining the application of strong electric field pulses to … indian oil navy marathonWebDec 18, 2024 · The authors report using high-intensity electric fields to perturb protein crystals and subsequently probe the dynamics of recovery using time-resolved x-ray crystallography. Such a pulse-probe approach, termed electric-field-stimulated protein mechanics, could help uncover the structures of previously unknown force-induced … location of ai tong schoolWebJan 21, 2009 · Stimulation with a 2 V/cm electric field for 40 min seemed to decrease both the surface area and the form-factor in the two cell types (i.e., smaller size cells and more complex spiky geometry). Apparently, electrically induced morphological changes are due to both actin cytoskeleton reorganization and membrane-cytoskeleton dissociation. indian oil new lpg connectionWebSep 16, 2024 · Hekstra, D. R. et al. Electric-field-stimulated protein mechanics. Nature 540 , 400–405 (2016). CAS PubMed PubMed Central Google Scholar indianoil offerWebSep 30, 2015 · Electric-field-stimulated protein mechanics. Hekstra, D.R. , White, K.I. , Socolich, M.A. , Henning, R.W. , Srajer, V. , Ranganathan, R. (2016) Nature 540: 400 … indian oil owa mail login