WebDec 22, 2006 · Crystalline Form of a Drug. 7727953 - 11615234 - USPTO Application Dec 22, 2006 - Publication Jun 01, 2010 ... The term “crystalline purity,” as used herein, means percentage of a particular crystalline form of a compound in a sample which may contain amorphous form of the compound, one or more than one other crystalline forms of the ... WebA patent has been issued. Another example of my synthetic abilities was where I defined and demonstrated a novel Suzuki coupling procedure and discovered a new crystalline HCl salt of the final ...
Amorphization of a crystalline active pharmaceutical ingredient …
WebThe CO 2 gas (99.99% purity) was purchased from "The Linde Group". that it was not a twin or a mixture of form I and form II but it was an intergrown crystal containing domains of both forms I and ... WebComment on solubility of amorphous forms of drugs compared to crystalline forms of the same drug: Amorphous form usually more soluble than crystalline form - no crystal lattice to be broken (number of bonds that need to be broken are reduced) - Examples of marketed products: quinapril HCl, cefuroxime axetil, melfinavir mesylate shannon chan-kent measurements
Pharmaceutical Crystals: Development, Optimization, …
WebFeb 17, 2024 · Single crystals of polymorphic Form 1, Form 2, and a monohydrate of the drug lead were isolated, and their structures were … WebMay 31, 2024 · INTRODUCTION. Solid form screening and selection is an integral part of drug development. Traditionally, it has focused on the search for a crystalline form, such as salts and polymorphs. 1-5 In recent years, it has been expanded to include co-crystals and amorphous solid dispersion (ASD) screens for poorly soluble compounds. Solid … WebExamples of pharmaceutical compounds displaying this type of polymorphism include aspirin (9, Fig. 3) and felodipine (10, Fig. 3), and they are discussed in more detail in … shannon chedville