Clptml1 cancer scholar

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August undefined, 2024

WebA novel endometrial cancer risk locus is reported and the spectrum of cancer types associated with genetic variation at 5p15 is expanded, further highlighting the importance … WebJul 9, 2014 · Introduction. Esophageal cancer was the fifth most commonly diagnosed cancer and the fourth leading cause of cancer-related death in China in 2009 .Esophageal cancer is very aggressive and is associated with a poor prognosis .Esophageal squamous cell carcinoma (ESCC) accounts for more than 90 percent of esophageal cancers …

CLPTM1L is overexpressed in lung cancer and associated with

WebFeb 6, 2016 · Variants of the cleft lip and palate trans-membrane 1 like (CLPTM1L) gene, located on chromosome 5p15.33, were previously determined to influence lung cancer susceptibility. Here, we performed a case-control study to examine the potential association of CLPTM1L single nucleotide polymorphisms (SNPs) with lung cancer in a Chinese … WebMar 29, 2024 · Introduction. The incidence of oral squamous cell carcinoma (OSCC) has increased in the recent years. Despite progress in chemotherapy and radiotherapy, the prognosis of advanced OSCC remains unfavorable [].This is contrary to the improved prognosis of patients with other cancers, such as breast cancer, lymphoma, lung … futton learning app

Combination of Clptm1L and TMEM207 Expression as a Robust …

WebFeb 6, 2016 · CLPTM1L encodes a protein linked to cisplatin-resistant ovarian tumor cell lines and is expressed in cells of various tumor types, including skin, lung, breast, … Web10). The variant was also significantly associated with triple-negative (ER-negative, progesterone receptor (PR)-negative and human epidermal growth factor-2 (HER2)-negative) breast cancer (OR = 1.25, P = 1.1 × 10 -9), particularly in younger women (<50 years of age) (OR = 1.48, P = 1.9 × 10 -9).Our results identify a genetic locus associated … WebJun 23, 2024 · Abstract. Lung cancer is a common cancer in human and has presented significant genetic predisposition. Previous genome-wide association study observed that rs401681 within CLPTM1L (CLPTM1 like) was significantly associated with lung cancer. By analyzing 1000 genomes data for East Asian, we identified only one SNP in nearby … fut toy

Association between CLPTM1L-TERT rs401681 polymorphism and …

Combination of Clptm1L and TMEM207 Expression as a …

WebSep 29, 2024 · Multiple genome-wide association studies (GWAS) have demonstrated that the TERT-CLPTM1L genetic variation at 5p15.33 is correlated with the risk of various malignant tumors, such as lung cancer, cervical cancer, pancreatic cancer, bladder cancer, glioma, prostate cancer, basal cell carcinoma and melanoma, and oral cancer … WebNational Center for Biotechnology Information giving others a dreamWebNov 1, 2024 · Cancer susceptibility of the rs401681 polymorphism, located in the TERT-CLPTM1L locus, has been studied in many cancers. We examined the clinicopathological and prognostic value of rs401681 variants in lung cancer. The relationship between rs401681 variants and telomere length was analyzed in 134 non-small cell lung cancers … futties player pick team 2

"WebJan 17, 2015 · The rs401681 polymorphism was located in the intron 13 of CLPTM1L and 27 kb from the TERT, which has been widely reported to be associated with an … " - Clptml1 cancer scholar

Clptml1 cancer scholar

CLPTM1L polymorphism as a protective factor for lung cancer: a …

WebThe transmembrane protein CLPTM1L is overexpressed in non-small cell lung cancer, where it protects tumor cells from genotoxic apoptosis. Here, we show that RNA … WebJan 12, 2016 · A recent meta-analysis of 85 studies including over 490,000 subjects that evaluated 67 TERT/CLPTM1L locus polymorphisms and 24 tumor types identified 11 SNPs with strong cumulative evidence for an association with at least one cancer type. rs31489 was one of these SNPs and was found to have strong cumulative evidence for …

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WebCLPTM1L transferred lung cancer cell line 95-D showed no growth inhibition or cell apoptosis, but it did show inhibited sensitivity to cis-diamminedichloroplatinum(II) (cisplatin, CDDP). Knockdown of CLPTM1L by RNAi did not interfere with cell proliferation but it did increase cell sensitivity to CDDP and activation of caspase-9 and caspase-3/7. WebDec 26, 2012 · In the hope of defining the pathogenesis of CLPTM1L in lung cancer, we focused on CLPTM1L expression, cellular localization and functional association with lung cancer. We found that CLPTM1L was …

WebMay 14, 2014 · Risk variants in the TERT - CLPTM1L gene region on chromosome 5p15.33 have been reported in genome-wide association studies (GWAS) for 10 cancer types, … WebSep 29, 2024 · CLPTM1L is the homologous protein gene of CLPTM1. CLPTM1 was reported for the first time in a cleft lip and palate family with a translocation breakpoint …

WebJul 14, 2024 · The mechanism of the lumenal translocation of GlcN-PI is unclear. We report that Cleft lip and palate transmembrane protein 1-like protein (CLPTM1L), an ER membrane protein of unknown function, is a lipid scramblase involved in GPI biosynthesis. Purified CLPTM1L scrambles GlcN-PI, PI, and several other phospholipids in vitro. WebAug 15, 2012 · Single-nucleotide polymorphism of CLPTM1L-rs401681(C > T) at the 5p15.33 locus is significantly associated with cancer risk as reported in genome-wide association studies, but the reported studies for non-melanoma skin cancer (NMSC) are inconclusive. To assess the association between rs401681[C] allele and NMSC risk, we …

WebDec 26, 2012 · CLPTM1L is believed to be associated with lung cancer. However, there is little information regarding its expression and function. Here using immunohistochemistry, we found that CLPTM1L expression …

Webprotein 1 (CLPTM1L) (9-11). These genes have multiple cancer risk loci and may be associated with tumorigenesis. TERT is the catalytic subunit of telomerase, and is … futtons sofa beds at wal martWebMay 15, 2014 · Our results suggest that CLPTM1L functions as a growth-promoting gene in the pancreas and that overexpression may lead to an abrogation of normal cytokinesis, … giving out covid testsWebMar 2, 2024 · Next, we evaluated the levels of CLPTM1L and cancer stem cell markers in a panel of high-grade serous ovarian carcinoma ... CAS PubMed Google Scholar Mobuchon, L. et al. A GWAS in uveal melanoma ... futtocks shroud giving our first fruits to godWebJun 4, 2012 · Cleft Lip and Palate Transmembrane Protein 1-Like (CLPTM1L), resides in a region of chromosome 5 for which copy number gain has been found to be the most … giving others my credit card offersWebMay 22, 2009 · Introduction. Lung cancer is the most common cancer worldwide, both in terms of incidence and mortality. Smoking and occupational–environmental exposure are well established to be the major etiological risk factors for lung cancer risk ( 1).The carcinogenic polycyclic aromatic hydrocarbons (PAHs) and the tobacco-specific … giving out in irishWebFeb 28, 2014 · To date, many studies have indicated that CLPTM1L and TERT genes were candidate susceptible genes for many diseases, in which SNPs and CNV were reported … giving others feedback